Dott. Sandro Michelini
Docente per i corsi di:
- Linfodrenaggio Manuale e Riabilitazione Integrata dell'Edema Flebolinfatico
* Medico Chirurgo specialista in Chirurgia Generale
* Past President della Società Europea di Linfologia
* Membro del Comitato esecutivo dell’International Society of Lymphology
* Membro del Comitato Esecutivo della Società Europea di Linfologia
* Vice-Presidente del Collegio Italiano di Flebologia
* Vice-Presidente della Società Italiana di Linfangiologia
* Presidente Eletto della International Society of Lymphology (2017-2019)
Dopo essersi laureato con pieni voti assoluti e lode in Medicina e Chirurgia nel 1981 presso l’Università La Sapienza di Roma ha conseguito successivamente il Diploma di Specializzazione in Chirurgia Generale nel 1984. Dal 1988 si occupa a tempo pieno di Angiologia e Riabilitazione Vascolare svolgendo la sua attività professionale per l’Ospedale San Giovanni Battista di Roma dove attualmente ricopre l’incarico di Responsabile U.O.S 2 D di degenza e Day Hospital di Riabilitazione Vascolare. E’ autore di oltre 200 pubblicazioni scientifiche, la maggior parte delle quali in ambito vascolare. Da oltre 10 anni lavora insegna come docente in corsi di Riabilitazione Vascolare ed è stato Presidente e Moderatore di numerosi congressi nazionali e internazionali. Nell’anno 2007 è stato nominato Coordinatore della Commissione del Ministero della Salute per la stesura delle Linee Guida sui linfedemi primari e secondari. Durante la sua prolifica carriera in ambito medico assistenziale e scientfico ha ricoperto numerosi incarichi di prestigio tra i quali: Past-President Società Europea di Linfologia (dal 2006 a Settembre 2014), Vice-Presidente del Collegio Italiano di Flebologia, Vice-Presidente della Società Italiana di Linfangiologia, Membro del Comitato esecutivo dell’International Society of Lymphology, Membro del Comitato Esecutivo della Società Europea di Linfologia,Presidente Eletto della Società Italiana di Flebolinfologia (biennio 2017-2019, Presidente dell’Italian Lymphodema Framework, Presidente Eletto International Society of Lymphology (triennio 2017-2019).
PRINCIPALI PUBBLICAZIONI
2026
- Mechanoreceptor plexin D1 regulates lymphatic valve morphogenesis and lymphedema pathogenesis
Pang KL, Mehta V, Aitken C, Dobbins SE, Yu J, Bonetti G, Keen AN, Zhang F, Sabine A, Petrova TV, Riley PR, Jones EY, Michelini S, Bertelli M, Reader JS, Ostergaard P, Tzima E.
Journal of Clinical Investigation. 2026 Jul 1;136(13):e193385. doi:10.1172/JCI193385. - Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam
Kruppa P, Crescenzi R, Faerber G, Forner-Cordero I, Cornely M, Shayan R, Karnezis T, Simarro JL, de Souza PF, Herbst KL, Ghods M, Michelini S.
Nature Communications. 2026 Jan 10;17(1):427. doi:10.1038/s41467-025-68232-z.
2025
- Clinical Signs at Diagnosis and Comorbidities in a Large Cohort of Patients with Lipedema in Spain
Simarro JL, Michelini S, Andrés-Gasco M, Lebrero García A, Ortega Abad D, Margalejo Lombardo J, Buj Vargas J, Sanchéz-Costa JT, Martín Martínez MA.
Biomedicines. 2025 Dec 11;13(12):3049. doi:10.3390/biomedicines13123049. - Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema
Michelini S, Greco S, Vaia N, Puleo V, Pellegrino P, Di Vincenzo A, Michelini S, Herbst KL, Goteri G, Luca T, Castorina S, Giordano A, Ciarmela P, Cinti S.
Obesity. 2025 Apr;33(4):695-708. doi:10.1002/oby.24244. - Special Issue “Adipose Tissue Diseases: Physiopathology, Molecular Mechanism, Diagnosis, and Treatment”
Cannataro R, Michelini S, Cione E.
International Journal of Molecular Sciences. 2025 Feb 27;26(5):2068. doi:10.3390/ijms26052068.
2024
- Identification of Specific microRNAs in Adipose Tissue Affected by Lipedema
Cione E, Michelini S, Abrego-Guandique DM, Vaia N, Michelini S, Puleo V, Bertelli M, Caroleo MC, Cannataro R.
Current Issues in Molecular Biology. 2024 Oct 25;46(11):11957-11974. doi:10.3390/cimb46110710. - Proposed Framework for Research Case Definitions of Lipedema
Keith L, Seo C, Wahi MM, Huggins S, Carmody M, Faerber G, Forner-Cordero I, Michelini S, Rapprich S, Rockson SG.
Lymphatic Research and Biology. 2024 Apr;22(2):93-105. doi:10.1089/lrb.2023.0062.
2022
- Dietary supplements for lipedema
Bonetti G, Herbst KL, Dhuli K, Kiani AK, Michelini S, Michelini S, Ceccarini MR, Michelini S, Ricci M, Cestari M, Codini M, Beccari T, Bellinato F, Gisondi P, Bertelli M.
Journal of Preventive Medicine and Hygiene. 2022 Oct 17;63(2 Suppl 3):E169-E173. doi:10.15167/2421-4248/jpmh2022.63.2S3.2758. - Dietary supplements in lymphedema
Bonetti G, Dhuli K, Michelini S, Michelini S, Michelini S, Ricci M, Cestari M, Bertelli M.
Journal of Preventive Medicine and Hygiene. 2022 Oct 17;63(2 Suppl 3):E200-E205. doi:10.15167/2421-4248/jpmh2022.63.2S3.2761. - Low Efficacy of Genetic Tests for the Diagnosis of Primary Lymphedema Prompts Novel Insights into the Underlying Molecular Pathways
Bonetti G, Paolacci S, Samaja M, Maltese PE, Michelini S, Michelini S, Michelini S, Ricci M, Cestari M, Dautaj A, Medori MC, Bertelli M.
International Journal of Molecular Sciences. 2022 Jul 3;23(13):7414. doi:10.3390/ijms23137414. - A Multi-Gene Panel to Identify Lipedema-Predisposing Genetic Variants by a Next-Generation Sequencing Strategy
Michelini S, Herbst KL, Precone V, Manara E, Marceddu G, Dautaj A, Maltese PE, Paolacci S, Ceccarini MR, Beccari T, Sorrentino E, Aquilanti B, Velluti V, Matera G, Gagliardi L, Miggiano GAD, Bertelli M.
Journal of Personalized Medicine. 2022 Feb 11;12(2):268. doi:10.3390/jpm12020268. - CDH5, a Possible New Candidate Gene for Genetic Testing of Lymphedema
Michelini S, Ricci M, Amato B, Gentileschi S, Veselenyiova D, Kenanoglu S, Fiorentino A, Kurti D, Baglivo M, Manara E, Basha SH, Priya S, Krajcovic J, Dundar M, Belgrado JP, Dautaj A, Bertelli M.
Lymphatic Research and Biology. 2022 Oct;20(5):496-506. doi:10.1089/lrb.2020.0089.
2021
- Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up
Cannataro R, Michelini S, Ricolfi L, Caroleo MC, Gallelli L, De Sarro G, Onorato A, Cione E.
Life. 2021 Dec 15;11(12):1402. doi:10.3390/life11121402. - LIMPRINT in Italy
Cestari M, Michelini S, Ricci M, Franks PJ, Murray S, Moffatt CJ, Michelini S.
Lymphatic Research and Biology. 2021 Oct;19(5):468-472. doi:10.1089/lrb.2021.0062. - Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations
Missaglia S, Tavian D, Michelini S, Maltese PE, Bonanomi A, Bertelli M.
Genes. 2021 Apr 27;12(5):650. doi:10.3390/genes12050650. - Genetic Determinants of the Effects of Training on Muscle and Adipose Tissue Homeostasis in Obesity Associated with Lymphedema
Vettori A, Paolacci S, Maltese PE, Herbst KL, Cestari M, Michelini S, Michelini S, Samaja M, Bertelli M.
Lymphatic Research and Biology. 2021 Aug;19(4):322-333. doi:10.1089/lrb.2020.0057. - Possible Role of the RORC Gene in Primary and Secondary Lymphedema: Review of the Literature and Genetic Study of Two Rare Causative Variants
Michelini S, Ricci M, Serrani R, Stuppia L, Beccari T, Veselenyiova D, Kenanoglu S, Barati S, Kurti D, Baglivo M, Basha SH, Krajcovic J, Dundar M, Bertelli M.
Lymphatic Research and Biology. 2021 Apr;19(2):129-133. doi:10.1089/lrb.2020.0030. - Study on the Therapeutic Efficacy of a Polyphitho Therapeutic Compound in Primary and Secondary Lymphedema
Michelini S, Gasbarro V, Izzo M, Albergati FG.
Lymphatic Research and Biology. 2021 Feb;19(1):66-72. doi:10.1089/lrb.2019.0080. - NOTCH1: Review of its role in lymphatic development and study of seven families with rare pathogenic variants
Michelini S, Ricci M, Serrani R, Barati S, Kenanoglu S, Veselenyiova D, Kurti D, Baglivo M, Basha SH, Priya S, Dautaj A, Dundar M, Krajcovic J, Bertelli M.
Molecular Genetics & Genomic Medicine. 2021 Jan;9(1):e1529. doi:10.1002/mgg3.1529.
2020
- Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema
Michelini S, Amato B, Ricci M, Kenanoglu S, Veselenyiova D, Kurti D, Baglivo M, Manara E, Dundar M, Krajcovic J, Basha SH, Priya S, Serrani R, Miggiano GAD, Aquilanti B, Matera G, Velluti V, Gagliardi L, Dautaj A, Bertelli M.
Genes. 2020 Nov 17;11(11):1361. doi:10.3390/genes11111361. - Study of a supplement and a genetic test for lymphedema management
Michelini S, Cestari M, Michelini S, Camilleri G, De Antoni L, Sonna WN, Bertelli M.
Acta Biomedica. 2020 Nov 9;91(13-S):e2020013. doi:10.23750/abm.v91i13-S.10658. - TIE1 as a Candidate Gene for Lymphatic Malformations with or without Lymphedema
Michelini S, Ricci M, Veselenyiova D, Kenanoglu S, Kurti D, Baglivo M, Fiorentino A, Basha SH, Priya S, Serrani R, Krajcovic J, Dundar M, Dautaj A, Bertelli M.
International Journal of Molecular Sciences. 2020 Sep 16;21(18):6780. doi:10.3390/ijms21186780. - Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema
Michelini S, Chiurazzi P, Marino V, Dell’Orco D, Manara E, Baglivo M, Fiorentino A, Maltese PE, Pinelli M, Herbst KL, Dautaj A, Bertelli M.
International Journal of Molecular Sciences. 2020 Aug 29;21(17):6264. doi:10.3390/ijms21176264. - FOXC2 Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation
Tavian D, Missaglia S, Michelini S, Maltese PE, Manara E, Mordente A, Bertelli M.
International Journal of Molecular Sciences. 2020 Jul 20;21(14):5112. doi:10.3390/ijms21145112. - Electrical Stimulation in the Treatment of Lymphedema and Associated Skin Ulcers
Baglivo M, Martelli F, Paolacci S, Manara E, Michelini S, Bertelli M.
Lymphatic Research and Biology. 2020 Jun;18(3):270-276. doi:10.1089/lrb.2019.0052. - Molecular pathways involved in lymphedema: Hydroxytyrosol as a candidate natural compound for treating the effects of lymph accumulation
Bertelli M, Kiani AK, Paolacci S, Manara E, Dautaj A, Beccari T, Michelini S.
Journal of Biotechnology. 2020 Jan 20;308:82-86. doi:10.1016/j.jbiotec.2019.11.017.
2019
- Increasing evidence of hereditary lymphedema caused by CELSR1 loss-of-function variants
Maltese PE, Michelini S, Ricci M, Maitz S, Fiorentino A, Serrani R, Lazzerotti A, Bruson A, Paolacci S, Benedetti S, Bertelli M.
American Journal of Medical Genetics Part A. 2019 Sep;179(9):1718-1724. doi:10.1002/ajmg.a.61269. - Pregnancy and feto-neonatal outcome in primary lymphedema affected woman
Cavaliere AF, Perossini S, La Milia MC, Vidiri A, Michelini S, Lanzone A, Inchingolo R, Scambia G.
Minerva Ginecologica. 2019 Oct;71(5):390-391. doi:10.23736/S0026-4784.19.04426-5. - LIMPRINT in Specialist Lymphedema Services in United Kingdom, France, Italy, and Turkey
Keeley V, Franks P, Quere I, Mercier G, Michelini S, Cestari M, Borman P, Hughes A, Clark K, Lisle J, Benson M, Noerregaard S, Karlsmark T, Murray S, Moffatt C.
Lymphatic Research and Biology. 2019 Apr;17(2):141-146. doi:10.1089/lrb.2019.0021. - Vascular anomalies: molecular bases, genetic testing and therapeutic approaches
Paolacci S, Zulian A, Bruson A, Manara E, Michelini S, Mattassi RE, Lee BB, Amato B, Bertelli M.
International Angiology. 2019 Apr;38(2):157-170. doi:10.23736/S0392-9590.19.04154-3.
2018
- Genetic tests in lymphatic vascular malformations and lymphedema
Michelini S, Paolacci S, Manara E, Eretta C, Mattassi R, Lee BB, Bertelli M.
Journal of Medical Genetics. 2018 Apr;55(4):222-232. doi:10.1136/jmedgenet-2017-105064.
2016
- FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function
Tavian D, Missaglia S, Maltese PE, Michelini S, Fiorentino A, Ricci M, Serrani R, Walter MA, Bertelli M.
Oncotarget. 2016 Aug 23;7(34):54228-54239. doi:10.18632/oncotarget.9797.
2010
- Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)-2009
Lee B, Andrade M, Bergan J, Boccardo F, Campisi C, Damstra R, Flour M, Gloviczki P, Laredo J, Piller N, Michelini S, Mortimer P, Villavicencio JL; International Union of Phlebology.
International Angiology. 2010 Oct;29(5):454-470.
Profilo scientifico
LIBRI
- Michelini, S., Failla, A., & Moneta, G. (2000). Manuale teorico-pratico di riabilitazione vascolare. Bologna, Ed. PR.
Docenti dei Corsi ECM Fisio Kinesis
